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Pitfalls of Concomitant Use or Discontinuation of Cytochrome P450 2D6 Inhibitors The concomitant usage of tramadol hydrochloride tablets with all cytochrome P450 2D6 inhibitors (e.g., amiodarone, quinidine) could lead to an increase in tramadol plasma amounts in addition to a minimize while in the levels of the Lively metabolite, M1.two.two Affecte